ADRA1A iso8 This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily. Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 8p21.2
Cellular Component:  caveola; cytoplasm; dopaminergic synapse; GABA-ergic synapse; glutamatergic synapse; integral component of postsynaptic membrane; integral component of presynaptic membrane; nuclear membrane; nucleus; plasma membrane; T-tubule; Z disc
Molecular Function:  alpha1-adrenergic receptor activity; protein binding; protein heterodimerization activity
Biological Process:  activation of phospholipase C activity; adult heart development; aging; apoptotic process; calcium ion transport into cytosol; cell growth involved in cardiac muscle cell development; cell-cell signaling; G protein-coupled receptor signaling pathway; intracellular signal transduction; micturition; negative regulation of autophagy; negative regulation of cell proliferation; negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure; negative regulation of Rho protein signal transduction; pilomotor reflex; positive regulation of action potential; positive regulation of cardiac muscle contraction; positive regulation of cardiac muscle hypertrophy; positive regulation of cytosolic calcium ion concentration; positive regulation of ERK1 and ERK2 cascade; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of MAPK cascade; positive regulation of non-membrane spanning protein tyrosine kinase activity; positive regulation of protein kinase C signaling; positive regulation of synaptic transmission, GABAergic; positive regulation of systemic arterial blood pressure; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of vasoconstriction; regulation of synaptic vesicle exocytosis; response to drug; response to hormone; signal transduction; smooth muscle contraction
Reference #:  P35348-8 (UniProtKB)
Alt. Names/Synonyms: ADA1A; ADRA1A; ADRA1A iso8; ADRA1C; ADRA1L1; adrenoceptor alpha 1A; Alpha-1A adrenergic receptor; Alpha-1A adrenoceptor; Alpha-1A adrenoreceptor; Alpha-1C adrenergic receptor; Alpha-adrenergic receptor 1c; ALPHA1AAR; G protein coupled receptor
Gene Symbols: ADRA1A
Molecular weight: 40,725 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
Select Structure to View Below

ADRA1A iso8

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene