API5 iso1 Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Belongs to the API5 family. Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA-binding
Chromosomal Location of Human Ortholog: 11p12
Cellular Component:  cytoplasm; nuclear speck; nucleus; spliceosomal complex
Molecular Function:  fibroblast growth factor binding; protein binding
Biological Process:  apoptotic process; negative regulation of apoptotic process; negative regulation of fibroblast apoptotic process
Reference #:  Q9BZZ5-1 (UniProtKB)
Alt. Names/Synonyms: API5; API5 iso1; Apoptosis inhibitor 5; FIF-510
Gene Symbols: API5
Molecular weight: 49,497 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Select Structure to View Below

API5 iso1

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene