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calpastatin
Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of Human Ortholog: 5q15 |
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Cellular Component:
cytosol; endoplasmic reticulum; membrane
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Molecular Function:
calcium-dependent cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protein binding
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Biological Process:
inhibition of cysteine-type endopeptidase activity; negative regulation of type B pancreatic cell apoptotic process; presynaptic active zone organization
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Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
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Reference #:
P20810
(UniProtKB)
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Alt. Names/Synonyms: BS-17; Calpain inhibitor; Calpastatin; CAST; heart-type calpastatin; ICAL; MGC9402; PLACK; Sperm BS-17 component
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Gene Symbols: CAST
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Molecular weight:
76,573 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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