calpastatin Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. Belongs to the protease inhibitor I27 (calpastatin) family. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 5q15
Cellular Component:  cytosol; endoplasmic reticulum; membrane
Molecular Function:  calcium-dependent cysteine-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; protein binding
Biological Process:  inhibition of cysteine-type endopeptidase activity; negative regulation of type B pancreatic cell apoptotic process; presynaptic active zone organization
Disease: Peeling Skin With Leukonychia, Acral Punctate Keratoses, Cheilitis, And Knuckle Pads
Reference #:  P20810 (UniProtKB)
Alt. Names/Synonyms: BS-17; Calpain inhibitor; Calpastatin; CAST; heart-type calpastatin; ICAL; MGC9402; PLACK; Sperm BS-17 component
Gene Symbols: CAST
Molecular weight: 76,573 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein