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RDBP
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Belongs to the RRM NELF-E family. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Mitochondrial; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 6p21.33 |
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Cellular Component:
chromosome; NELF complex; nuclear body; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
chromatin binding; protein binding; RNA binding
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Biological Process:
localization; negative regulation of transcription by RNA polymerase II; negative regulation of transcription elongation by RNA polymerase II; positive regulation of ERK1 and ERK2 cascade; positive regulation of histone H3-K4 methylation; positive regulation of transcription by RNA polymerase II
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Reference #:
P18615
(UniProtKB)
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Alt. Names/Synonyms: D6S45; DADB-122G4.4; major histocompatibility complex gene RD; negative elongation factor complex member E; Negative elongation factor E; negative elongation factor polypeptide E; NELF-E; NELFE; nuclear protein; RD; RD RNA binding protein; RD RNA-binding protein; RDBP; RDP; RNA-binding protein RD
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Gene Symbols: NELFE
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Molecular weight:
43,240 Da
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Basal Isoelectric point:
9.36
Predict pI for various phosphorylation states
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