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JunB
Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). By growth factors. Belongs to the bZIP family. Jun subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Oncoprotein; Transcription factor |
| Chromosomal Location of Human Ortholog: 19p13.13 |
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Cellular Component:
chromatin; nucleoplasm; transcription factor AP-1 complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; transcription corepressor activity
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Biological Process:
cellular response to calcium ion; cytokine-mediated signaling pathway; decidualization; embryonic process involved in female pregnancy; labyrinthine layer blood vessel development; osteoblast differentiation; osteoblast proliferation; osteoclast differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; trophectodermal cell differentiation; vasculogenesis
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Reference #:
P17275
(UniProtKB)
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Alt. Names/Synonyms: activator protein 1; AP-1; jun B proto-oncogene; JUNB; Transcription factor jun-B
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Gene Symbols: JUNB
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Molecular weight:
35,879 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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