JunB Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. Binds DNA as an homodimer or as an heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). By growth factors. Belongs to the bZIP family. Jun subfamily. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.13
Cellular Component:  chromatin; nucleoplasm; transcription factor AP-1 complex
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; transcription corepressor activity
Biological Process:  cellular response to calcium ion; cytokine-mediated signaling pathway; decidualization; embryonic process involved in female pregnancy; labyrinthine layer blood vessel development; osteoblast differentiation; osteoblast proliferation; osteoclast differentiation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; trophectodermal cell differentiation; vasculogenesis
Reference #:  P17275 (UniProtKB)
Alt. Names/Synonyms: activator protein 1; AP-1; jun B proto-oncogene; JUNB; Transcription factor jun-B
Gene Symbols: JUNB
Molecular weight: 35,879 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene