MGMT Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. Belongs to the MGMT family. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA repair, damage; EC; Methyltransferase; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 10q26.3
Cellular Component:  nucleoplasm
Molecular Function:  calcium ion binding; DNA binding; DNA-methyltransferase activity; methyltransferase activity
Biological Process:  cellular response to ionizing radiation; cellular response to organic cyclic compound; cellular response to oxidative stress; DNA dealkylation involved in DNA repair; DNA ligation; DNA methylation; mammary gland epithelial cell differentiation; negative regulation of apoptotic process; positive regulation of double-strand break repair; regulation of cysteine-type endopeptidase activity involved in apoptotic process; response to ethanol; response to folic acid
Reference #:  P16455 (UniProtKB)
Alt. Names/Synonyms: 6-O-methylguanine-DNA methyltransferase; Methylated-DNA--protein-cysteine methyltransferase; methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; O6-methylguanine-DNA methyltransferase
Gene Symbols: MGMT
Molecular weight: 21,646 Da
Basal Isoelectric point: 8.28  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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