CAMK2A a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 5q32
Cellular Component:  calcium- and calmodulin-dependent protein kinase complex; cell junction; cytosol; dendritic spine; endocytic vesicle membrane; mitochondrion; nucleoplasm; postsynaptic density; postsynaptic membrane; Schaffer collateral - CA1 synapse
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; glutamate receptor binding; identical protein binding; kinase activity; metal ion binding; protein binding; protein homodimerization activity; protein serine/threonine kinase activity
Biological Process:  angiotensin-activated signaling pathway; calcium ion transport; dendrite morphogenesis; dendritic spine development; G1/S transition of mitotic cell cycle; interferon-gamma-mediated signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine autophosphorylation; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; protein autophosphorylation; protein phosphorylation; regulation of cellular response to heat; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of neuron migration; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; regulation of synaptic vesicle docking; response to ischemia; Wnt signaling pathway, calcium modulating pathway
Disease: Mental Retardation, Autosomal Dominant 53; Mental Retardation, Autosomal Recessive 63
Reference #:  Q9UQM7 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase II alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calmodulin-dependent kinase II; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaM-kinase II alpha chain; CaMK-II alpha subunit; CaMK-II subunit alpha; CAMK2A; CAMKA; CaMKII; CaMKIINalpha; KCC2A; KIAA0968
Gene Symbols: CAMK2A
Molecular weight: 54,088 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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