ERR1 Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription regulation
Chromosomal Location of Human Ortholog: 11q13.1
Cellular Component:  cytoplasm; fibrillar center; intercellular bridge; microtubule cytoskeleton; nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; protein domain specific binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; steroid binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  cartilage development; intracellular receptor signaling pathway; mitochondrion organization; negative regulation of transcription by RNA polymerase II; positive regulation of cellular response to insulin stimulus; positive regulation of transcription by RNA polymerase II; regulation of cell proliferation; regulation of osteoblast differentiation; regulation of osteoclast differentiation; regulation of transcription, DNA-templated; response to estradiol; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter
Reference #:  P11474 (UniProtKB)
Alt. Names/Synonyms: ERR-alpha; ERR1; ERRa; ERRalpha; ESRL1; ESRRA; Estrogen receptor-like 1; Estrogen-related receptor alpha; NR3B1; Nuclear receptor subfamily 3 group B member 1; Steroid hormone receptor ERR1
Gene Symbols: ESRRA
Molecular weight: 45,510 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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