EAR-2 Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily. Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 19p13.11
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; nuclear receptor activity; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process:  detection of temperature stimulus involved in sensory perception of pain; entrainment of circadian clock by photoperiod; intracellular receptor signaling pathway; negative regulation of transcription by RNA polymerase II; neuron development; signal transduction; steroid hormone mediated signaling pathway; transcription initiation from RNA polymerase II promoter
Reference #:  P10588 (UniProtKB)
Alt. Names/Synonyms: EAR-2; EAR2; ERBA-related gene-2; ERBAL2; NR2F6; Nuclear receptor subfamily 2 group F member 6; nuclear receptor subfamily 2, group F, member 6; nuclear receptor V-erbA-related; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2; V-erbA-related protein 2
Gene Symbols: NR2F6
Molecular weight: 42,979 Da
Basal Isoelectric point: 7.96  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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