Ferritin-H Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Belongs to the ferritin family. Expressed in the liver. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 11q12.3
Cellular Component:  autolysosome; cytosol; extracellular region; ficolin-1-rich granule lumen; intracellular ferritin complex; tertiary granule lumen
Molecular Function:  protein binding
Biological Process:  cellular iron ion homeostasis; immune response; intracellular sequestering of iron ion; iron ion transport; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; neutrophil degranulation; oxidation-reduction process
Disease: Hemochromatosis, Type 5
Reference #:  P02794 (UniProtKB)
Alt. Names/Synonyms: apoferritin; Cell proliferation-inducing gene 15 protein; Ferritin H subunit; Ferritin heavy chain; ferritin heavy chain 1; Ferritin heavy chain, N-terminally processed; ferritin, heavy polypeptide 1; Ferritin-H; FHC; FRIH; FTH; FTH1; FTHL6; HFE5; MGC104426; PIG15; placenta immunoregulatory factor; PLIF; proliferation-inducing protein 15
Gene Symbols: FTH1
Molecular weight: 21,226 Da
Basal Isoelectric point: 5.31  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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