lamin A/C nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. Cleaved by caspase-6 during apoptosis into a 40-45 kDa and a28 kDa fragment. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1q22
Cellular Component:  cytosol; lamin filament; nuclear envelope; nuclear speck; nucleoplasm; nucleus
Molecular Function:  protein binding; structural molecule activity
Biological Process:  cellular response to hypoxia; establishment or maintenance of microtubule cytoskeleton polarity; IRE1-mediated unfolded protein response; mitotic nuclear envelope reassembly; negative regulation of cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of mesenchymal cell proliferation; negative regulation of release of cytochrome c from mitochondria; positive regulation of cell aging; positive regulation of gene expression; protein import into nucleus; protein localization to nucleus; regulation of cell migration; regulation of protein localization to nucleus; ventricular cardiac muscle cell development
Disease: Cardiomyopathy, Dilated, 1a; Cardiomyopathy, Dilated, With Hypergonadotropic Hypogonadism; Charcot-marie-tooth Disease, Axonal, Type 2b1; Emery-dreifuss Muscular Dystrophy 2, Autosomal Dominant; Emery-dreifuss Muscular Dystrophy 3, Autosomal Recessive; Heart-hand Syndrome, Slovenian Type; Hutchinson-gilford Progeria Syndrome; Lipodystrophy, Familial Partial, Type 2; Mandibuloacral Dysplasia With Type A Lipodystrophy; Muscular Dystrophy, Congenital, Lmna-related; Restrictive Dermopathy, Lethal
Reference #:  P02545 (UniProtKB)
Alt. Names/Synonyms: 70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; HGPS; IDC; lamin A/C; Lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; Prelamin-A/C; PRO1; Renal carcinoma antigen NY-REN-32
Gene Symbols: LMNA
Molecular weight: 74,139 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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lamin A/C

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein