NFAT90 iso7 RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs. Ubiquitous. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.2
Cellular Component:  cytoplasm; mitochondrion; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function:  DNA binding; double-stranded RNA binding; mRNA 3'-UTR AU-rich region binding; protein binding; RNA binding
Biological Process:  defense response to virus; negative regulation of transcription, DNA-templated; negative regulation of translation; negative regulation of viral genome replication; positive regulation of transcription, DNA-templated; protein phosphorylation
Reference #:  Q12906-7 (UniProtKB)
Alt. Names/Synonyms: CBTF; Double-stranded RNA-binding protein 76; double-stranded RNA-binding protein, 76 kD; DRBF; DRBP76; dsRNA binding protein NFAR-2/MPP4; ILF3; interleukin enhancer binding factor 3; interleukin enhancer binding factor 3, 90kD; interleukin enhancer binding factor 3, 90kDa; Interleukin enhancer-binding factor 3; M phase phosphoprotein 4, nuclear factor associated with DS RNA; M-phase phosphoprotein 4; MMP4; MPHOSPH4; MPP4; MPP4110; NF-AT-90; NF110; NF110b; NF90; NF90a; NF90b; NF90c; NF90ctv; NFAR; NFAR-1; NFAR-2; NFAR110; NFAR2; NFAR90; NFAT90; NFAT90 iso7; Nuclear factor associated with dsRNA; nuclear factor of activated T-cells 110 kDa; Nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; TCP110; TCP80; Translational control protein 80
Gene Symbols: ILF3
Molecular weight: 95,808 Da
Basal Isoelectric point: 8.9  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Select Structure to View Below

NFAT90 iso7

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene