ACSL3 Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL3 mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Has mainly an anabolic role in energy metabolism. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins). Belongs to the ATP-dependent AMP-binding enzyme family. Note: This description may include information from UniProtKB.
Protein type: EC; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral
Chromosomal Location of human Ortholog: 2q36.1
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; integral component of membrane; lipid droplet; mitochondrial outer membrane; perinuclear region of cytoplasm; peroxisomal membrane
Molecular Function:  acyl-CoA ligase activity; ATP binding; decanoate-CoA ligase activity; long-chain fatty acid-CoA ligase activity; protein domain specific binding; protein kinase binding
Biological Process:  brain development; fatty acid biosynthetic process; long-chain fatty acid import; long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA biosynthetic process; positive regulation of Golgi to plasma membrane protein transport; positive regulation of phosphatidylcholine biosynthetic process; positive regulation of secretion; response to nutrient; response to organic cyclic compound; very-low-density lipoprotein particle assembly
Reference #:  O95573 (UniProtKB)
Alt. Names/Synonyms: ACS3; ACSL3; acyl-CoA synthetase long chain family member 3; acyl-CoA synthetase long-chain family member 3; Arachidonate--CoA ligase; FACL3; fatty-acid-Coenzyme A ligase, long-chain 3; LACS 3; LACS3; lignoceroyl-CoA synthase; Long-chain acyl-CoA synthetase 3; Long-chain-fatty-acid--CoA ligase 3; PRO2194
Gene Symbols: ACSL3
Molecular weight: 80,420 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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