TRIM16 E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage. Belongs to the TRIM/RBCC family. Highest levels found in testis, ovary, small intestine, colon, placenta, heart, skeletal muscle and mammary gland. More highly expressed in the fetus than in the corresponding adult tissues. Expressed in basal keratinocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 17p12
Cellular Component:  cytoplasm; cytosol; plasma membrane; PML body
Molecular Function:  DNA binding; interleukin-1 binding; NACHT domain binding; protein binding; transferase activity; zinc ion binding
Biological Process:  histone H3 acetylation; histone H4 acetylation; positive regulation of interleukin-1 beta secretion; positive regulation of keratinocyte differentiation; positive regulation of retinoic acid receptor signaling pathway; positive regulation of transcription, DNA-templated; response to growth hormone; response to organophosphorus; response to retinoic acid
Reference #:  O95361 (UniProtKB)
Alt. Names/Synonyms: E3 ubiquitin-protein ligase TRIM16; EBBP; Estrogen-responsive B box protein; TRI16; TRIM16; tripartite motif containing 16; tripartite motif-containing 16; Tripartite motif-containing protein 16
Gene Symbols: TRIM16
Molecular weight: 63,955 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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