UBE4B Binds to the ubiquitin moieties of preformed conjugates and catalyzes ubiquitin chain assembly in conjunction with E1, E2, and E3. Belongs to the ubiquitin conjugation factor E4 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component:  cytoplasm; ubiquitin ligase complex
Molecular Function:  ATP binding; ATPase binding; enzyme binding
Biological Process:  granzyme-mediated apoptotic signaling pathway; neuron projection development; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; response to UV; ubiquitin-dependent protein catabolic process; ventricular trabecula myocardium morphogenesis
Reference #:  O95155 (UniProtKB)
Alt. Names/Synonyms: E4; HDNB1; homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; KIAA0684; UBE4B; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitin-fusion degradation protein 2; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); UBOX3; UFD2
Gene Symbols: UBE4B
Molecular weight: 146,185 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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