UBE4B Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. May regulate myosin assembly in striated muscles together with STUB1 and VCP/p97 by targeting myosin chaperone UNC45B for proteasomal degradation. Belongs to the ubiquitin conjugation factor E4 family. Expressed in differentiated myotubes (at protein level) (PubMed:17369820). Highest expression in ovary, testis, heart and skeletal muscle (PubMed:11802788). Expression is low in colon, thymus and peripheral blood leukocytes (PubMed:11802788). Almost undetectable in lung and spleen (PubMed:11802788). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 1p36.22
Cellular Component:  cytoplasm; ubiquitin ligase complex
Molecular Function:  ATP binding; ATPase binding; enzyme binding
Biological Process:  granzyme-mediated apoptotic signaling pathway; neuron projection development; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein monoubiquitination; response to UV; ubiquitin-dependent protein catabolic process; ventricular trabecula myocardium morphogenesis
Reference #:  O95155 (UniProtKB)
Alt. Names/Synonyms: E4; HDNB1; homologous to yeast UFD2; Homozygously deleted in neuroblastoma 1; homozygously deleted in neuroblastoma-1; KIAA0684; RING-type E3 ubiquitin transferase E4 B; UBE4B; Ubiquitin conjugation factor E4 B; Ubiquitin fusion degradation protein 2; ubiquitin-fusion degradation protein 2; ubiquitination factor E4B; ubiquitination factor E4B (homologous to yeast UFD2); ubiquitination factor E4B (UFD2 homolog, yeast); UBOX3; UFD2; UFD2A
Gene Symbols: UBE4B
Molecular weight: 146,185 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein