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SFRS15
Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA processing; RNA-binding |
| Chromosomal Location of human Ortholog: 21q22.11 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
RNA binding; RNA polymerase II C-terminal domain phosphoserine binding
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Biological Process:
negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
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Disease: Fliedner-zweier Syndrome
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Reference #:
O95104
(UniProtKB)
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Alt. Names/Synonyms: CTD-binding SR-like protein RA4; DKFZp434E098; FLJ23364; KIAA1172; pre-mRNA splicing SR protein rA4; SCAF4; SFR15; SFRS15; splicing factor serine alanine 15; Splicing factor, arginine/serine-rich 15; SR-like CTD-associated factor 4; SR-related and CTD-associated factor 4; SR-related CTD associated factor 4; SRA4
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Gene Symbols: SCAF4
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Molecular weight:
125,869 Da
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Basal Isoelectric point:
9.58
Predict pI for various phosphorylation states
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