SFRS15 Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF8, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF8, also acts as a suppressor of transcriptional readthrough. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; RNA-binding
Chromosomal Location of human Ortholog: 21q22.11
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  protein C-terminus binding; RNA binding; RNA polymerase II C-terminal domain phosphoserine binding
Biological Process:  mRNA processing; negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled
Reference #:  O95104 (UniProtKB)
Alt. Names/Synonyms: CTD-binding SR-like protein RA4; DKFZp434E098; FLJ23364; KIAA1172; pre-mRNA splicing SR protein rA4; SCAF4; SFR15; SFRS15; splicing factor serine alanine 15; Splicing factor, arginine/serine-rich 15; SR-like CTD-associated factor 4; SR-related and CTD-associated factor 4; SR-related CTD associated factor 4; SRA4
Gene Symbols: SCAF4
Molecular weight: 125,869 Da
Basal Isoelectric point: 9.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein