JMJD2B Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase
Chromosomal Location of human Ortholog: 19p13.3
Cellular Component:  chromatin; nucleoplasm; nucleus
Molecular Function:  histone demethylase activity; histone H3K36 demethylase activity; histone H3K9 demethylase activity; histone H3K9me2/H3K9me3 demethylase activity; metal ion binding
Biological Process:  brain development; chromatin remodeling; regulation of gene expression
Disease: Intellectual Developmental Disorder, Autosomal Dominant 65
Reference #:  O94953 (UniProtKB)
Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(9) demethylase 4B; FLJ44906; JHDM3B; JmjC domain-containing histone demethylation protein 3B; JMJD2B; jumonji domain containing 2B; Jumonji domain-containing protein 2B; KDM4B; KIAA0876; lysine (K)-specific demethylase 4B; lysine demethylase 4B; Lysine-specific demethylase 4B; TDRD14B; tudor domain containing 14B
Gene Symbols: KDM4B
Molecular weight: 121,897 Da
Basal Isoelectric point: 6.72  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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