CCNK iso1 Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). Belongs to the cyclin family. Cyclin C subfamily. Widely expressed. Highest levels in testis. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 14q32.2
Cellular Component:  cyclin K-CDK12 complex; cyclin K-CDK13 complex; cyclin/CDK positive transcription elongation factor complex; nucleoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase activity; protein binding; protein kinase binding; RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process:  cell cycle; cell division; DNA damage response; negative regulation by host of viral genome replication; positive regulation of DNA-templated transcription, elongation; positive regulation of transcription elongation by RNA polymerase II; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of signal transduction; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II
Disease: Intellectual Developmental Disorder With Hypertelorism And Distinctive Facies
Reference #:  O75909-1 (UniProtKB)
Alt. Names/Synonyms: CCNK; CCNK iso1; CPR4; cyclin K; Cyclin-K; IDDHDF; MGC9113
Gene Symbols: CCNK
Molecular weight: 41,293 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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CCNK iso1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB