U5-200kD Plays role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Belongs to the helicase family. SKI2 subfamily. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; RNA processing; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component:  catalytic step 2 spliceosome; nucleoplasm; nucleus; spliceosomal complex; U4/U6 x U5 tri-snRNP complex; U5 snRNP
Molecular Function:  ATP binding; ATP-dependent helicase activity; ATP-dependent RNA helicase activity; identical protein binding; protein binding
Biological Process:  cis assembly of pre-catalytic spliceosome; mRNA splicing, via spliceosome
Disease: Retinitis Pigmentosa 33
Reference #:  O75643 (UniProtKB)
Alt. Names/Synonyms: Activating signal cointegrator 1 complex subunit 3-like 1; ASCC3L1; BRR2; BRR2 homolog; FLJ11521; HELIC2; KIAA0788; RP33; small nuclear ribonucleoprotein 200kDa (U5); SNRNP200; U5 small nuclear ribonucleoprotein 200 kDa helicase; U5 snRNP-specific 200 kDa protein; U5-200KD; U520
Gene Symbols: SNRNP200
Molecular weight: 244,508 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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U5-200kD

Protein Structure Not Found.


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