FNBP3 Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. Belongs to the PRPF40 family. Expressed in the brain cortex (at protein level). Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing; Spliceosome
Chromosomal Location of Human Ortholog: 2q23.3
Cellular Component:  cytosol; nuclear matrix; nuclear speck; nucleoplasm
Molecular Function:  proline-rich region binding; protein binding
Biological Process:  cell cycle; cell division; cell migration; cytoskeleton organization; mRNA cis splicing, via spliceosome; mRNA splicing, via spliceosome; regulation of cell shape; regulation of cytokinesis
Reference #:  O75400 (UniProtKB)
Alt. Names/Synonyms: Fas ligand-associated factor 1; Fas-ligand associated factor 1; FBP-11; FBP11; FLAF1; FLJ20585; FNBP3; formin binding protein 3; Formin-binding protein 11; Formin-binding protein 3; HIP-10; HIP10; Huntingtin yeast partner A; Huntingtin-interacting protein 10; Huntingtin-interacting protein A; HYPA; NY-REN-6; NY-REN-6 antigen; PR40A; pre-mRNA processing factor 40 homolog A; Pre-mRNA-processing factor 40 homolog A; Prp40; PRP40 pre-mRNA processing factor 40 homolog A; PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae); PRPF40A; Renal carcinoma antigen NY-REN-6
Gene Symbols: PRPF40A
Molecular weight: 108,805 Da
Basal Isoelectric point: 7.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene