EIF5B Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. Belongs to the IF-2 family. Note: This description may include information from UniProtKB.
Protein type: Translation; Translation initiation
Chromosomal Location of Human Ortholog: 2q11.2
Cellular Component:  cytoplasm; cytosol
Molecular Function:  GTP binding; GTPase activity; metal ion binding; protein binding; translation initiation factor activity
Biological Process:  regulation of translational initiation; translational initiation
Reference #:  O60841 (UniProtKB)
Alt. Names/Synonyms: DKFZp434I036; eIF-5B; EIF5B; Eukaryotic translation initiation factor 5B; FLJ10524; IF2; IF2P; KIAA0741; Translation initiation factor IF-2; translation initiation factor IF2
Gene Symbols: EIF5B
Molecular weight: 138,827 Da
Basal Isoelectric point: 5.39  Predict pI for various phosphorylation states
CST Pathways:  Translation: eIF2  |  Translational Control
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene