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EIF5B
Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Translation; Translation initiation |
| Chromosomal Location of human Ortholog: 2q11.2 |
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Cellular Component:
cytoplasm; cytosol; nucleus; synapse
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Molecular Function:
GTP binding; GTPase activity; metal ion binding; protein binding; translation initiation factor activity; tRNA binding
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Biological Process:
regulation of translational initiation; ribosome assembly; translational initiation
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Reference #:
O60841
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434I036; eIF-5B; EIF5B; Eukaryotic translation initiation factor 5B; FLJ10524; IF2; IF2P; KIAA0741; Translation initiation factor IF-2; translation initiation factor IF2
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Gene Symbols: EIF5B
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Molecular weight:
138,827 Da
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Basal Isoelectric point:
5.39
Predict pI for various phosphorylation states
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CST Pathways:
Translation: eIF2
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Translational Control
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