TLE4 iso2 Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Belongs to the WD repeat Groucho/TLE family. In all tissues examined, mostly in brain, and muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q21.31
Cellular Component:  beta-catenin-TCF complex; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  beta-catenin-TCF complex assembly; cellular response to leukemia inhibitory factor; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway
Reference #:  O60756 (UniProtKB)
Alt. Names/Synonyms: B lymphocyte gene 1; BCE-1; BCE1; E(spI); E(spl); enhancer of split groucho 4; ESG; ESG4; Grg-4; GRG4; groucho-related protein 4; Protein BCE-1; Putative protein BCE-1; TLE family member 4, transcriptional corepressor; TLE4; TLE4 iso2; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1); transducin-like enhancer protein 4
Gene Symbols: TLE4
Molecular weight: 9,784 Da
Basal Isoelectric point: 10.67  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
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TLE4 iso2

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene