|
TLE4 iso2
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Belongs to the WD repeat Groucho/TLE family. In all tissues examined, mostly in brain, and muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 9q21.31 |
|
Cellular Component:
beta-catenin-TCF complex; nucleoplasm; nucleus; transcription regulator complex
|
|
Molecular Function:
chromatin binding; DNA-binding transcription factor binding; protein binding; transcription corepressor activity
|
|
Biological Process:
cellular response to leukemia inhibitory factor; negative regulation of canonical Wnt signaling pathway; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway
|
|
Reference #:
O60756
(UniProtKB)
|
|
Alt. Names/Synonyms: B lymphocyte gene 1; BCE-1; BCE1; E(spI); E(spl); enhancer of split groucho 4; ESG; ESG4; Grg-4; GRG4; groucho-related protein 4; Protein BCE-1; Putative protein BCE-1; TLE family member 4, transcriptional corepressor; TLE4; TLE4 iso2; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1); transducin-like enhancer protein 4
|
|
Gene Symbols: TLE4
|
|
Molecular weight:
9,784 Da
|
|
Basal Isoelectric point:
10.67
Predict pI for various phosphorylation states
|
|
CST Pathways:
Wnt/ß-Catenin Signaling
|
