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TLE4 iso2
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression. Belongs to the WD repeat Groucho/TLE family. In all tissues examined, mostly in brain, and muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of Human Ortholog: 9q21.31 |
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Cellular Component:
beta-catenin-TCF complex; nucleoplasm; nucleus
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Molecular Function:
chromatin binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
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Biological Process:
beta-catenin-TCF complex assembly; cellular response to leukemia inhibitory factor; negative regulation of transcription by RNA polymerase II; Wnt signaling pathway
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Reference #:
O60756
(UniProtKB)
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Alt. Names/Synonyms: B lymphocyte gene 1; BCE-1; BCE1; E(spI); E(spl); enhancer of split groucho 4; ESG; ESG4; Grg-4; GRG4; groucho-related protein 4; Protein BCE-1; Putative protein BCE-1; TLE family member 4, transcriptional corepressor; TLE4; TLE4 iso2; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1); transducin-like enhancer protein 4
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Gene Symbols: TLE4
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Molecular weight:
9,784 Da
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Basal Isoelectric point:
10.67
Predict pI for various phosphorylation states
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CST Pathways:
Wnt/ß-Catenin Signaling
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