SNX2 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Belongs to the sorting nexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of human Ortholog: 5q23.2
Cellular Component:  cytoplasm; cytosol; early endosome membrane; endosome; endosome membrane; lamellipodium; lysosome; membrane; protein-containing complex; retromer complex; retromer, tubulation complex
Molecular Function:  epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; leptin receptor binding; phosphatidylinositol binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transferrin receptor binding
Biological Process:  early endosome to Golgi transport; intracellular protein transport; lamellipodium morphogenesis; retrograde transport, endosome to Golgi
Reference #:  O60749 (UniProtKB)
Alt. Names/Synonyms: CTB-36H16.2; MGC5204; SNX2; sorting nexin 2; Sorting nexin-2; Transformation-related gene 9 protein; TRG-9
Gene Symbols: SNX2
Molecular weight: 58,471 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein