periplakin Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. Belongs to the plakin or cytolinker family. Expressed in stratified squamous epithelia and in some other epithelia. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component:  cornified envelope; cytoskeleton; cytosol; desmosome; mitochondrion; nucleus
Molecular Function:  protein binding; structural constituent of cytoskeleton
Biological Process:  cornification; response to mechanical stimulus
Reference #:  O60437 (UniProtKB)
Alt. Names/Synonyms: 190 kDa paraneoplastic pemphigus antigen; 195 kDa cornified envelope precursor protein; KIAA0568; MGC134872; PEPL; Periplakin; PPL
Gene Symbols: PPL
Molecular weight: 204,747 Da
Basal Isoelectric point: 5.47  Predict pI for various phosphorylation states
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periplakin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein