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AS160
May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake. Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rab |
| Chromosomal Location of human Ortholog: 13q22.2 |
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Cellular Component:
cytosol; vesicle
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Molecular Function:
GTPase activator activity; protein binding
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Biological Process:
activation of GTPase activity; cellular response to insulin stimulus; negative regulation of vesicle fusion; vesicle-mediated transport
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Disease: Diabetes Mellitus, Noninsulin-dependent, 5
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Reference #:
O60343
(UniProtKB)
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Alt. Names/Synonyms: Acrg embryonic lethality minimal region ortholog; Akt substrate of 160 kDa; AS160; DKFZp779C0666; KIAA0603; NIDDM5; TBC (Tre-2, BUB2, CDC16) domain-containing protein; TBC1 domain family member 4; TBC1 domain family, member 4; TBC1D4; TBCD4
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Gene Symbols: TBC1D4
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Molecular weight:
146,563 Da
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Basal Isoelectric point:
6.57
Predict pI for various phosphorylation states
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CST Pathways:
Insulin Receptor Signaling
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PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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