KIF1B Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. Isoform 3 is abundant in the skeletal muscle. It is also expressed in fetal brain, lung and kidney, and adult heart, placenta, testis, ovary and small intestine. Isoform 2 is abundant in the brain and also expressed in fetal heart, lung, liver and kidney, and adult skeletal muscle, placenta, liver, kidney, heart, spleen, thymus, prostate, testis, ovary, small intestine, colon and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of human Ortholog: 1p36.22
Cellular Component:  axon; axon cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; dendrite; kinesin complex; microtubule; microtubule associated complex; mitochondrion; neuron projection; synaptic vesicle
Molecular Function:  ATP binding; ATP hydrolysis activity; kinesin binding; microtubule binding; plus-end-directed microtubule motor activity; protein binding
Biological Process:  anterograde axonal transport; apoptotic process; cytoskeleton-dependent intracellular transport; microtubule-based movement; neuromuscular synaptic transmission; neuron-neuron synaptic transmission; vesicle-mediated transport
Disease: Charcot-marie-tooth Disease, Axonal, Type 2a1; Neuroblastoma, Susceptibility To
Reference #:  O60333 (UniProtKB)
Alt. Names/Synonyms: CMT2; CMT2A; CMT2A1; FLJ23699; HMSNII; KIAA0591; KIAA1448; KIF1B; kinesin family member 1B; kinesin superfamily protein KIF1B; Kinesin-like protein KIF1B; Klp; MGC134844; NBLST1
Gene Symbols: KIF1B
Molecular weight: 204,476 Da
Basal Isoelectric point: 5.42  Predict pI for various phosphorylation states
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KIF1B

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein