AKAP8 Anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II). Belongs to the AKAP95 family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding
Chromosomal Location of Human Ortholog: 19p13.12
Cellular Component:  condensed chromosome; female pronucleus; Golgi apparatus; mitochondrion; nuclear matrix; nucleolus; nucleoplasm; nucleus
Molecular Function:  double-stranded DNA binding; histone deacetylase binding; NF-kappaB binding; protein binding; protein kinase A regulatory subunit binding; zinc ion binding
Biological Process:  cell cycle G2/M phase transition; cellular response to lipopolysaccharide; cellular response to prostaglandin E stimulus; innate immune response; mitotic cell cycle; mitotic chromosome condensation; negative regulation of tumor necrosis factor production; positive regulation of histone deacetylation; protein transport; regulation of histone phosphorylation; signal transduction
Reference #:  O43823 (UniProtKB)
Alt. Names/Synonyms: A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; AKAP 95; AKAP-8; AKAP8; AKAP95; DKFZp586B1222
Gene Symbols: AKAP8
Molecular weight: 76,108 Da
Basal Isoelectric point: 5.03  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene