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SGTA
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70. Belongs to the SGT family. Ubiquitous. Note: This description may include information from UniProtKB.
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| Protein type: Chaperone |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
cytoplasm; cytosol; membrane; nucleus; TRC complex
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Molecular Function:
BAT3 complex binding; identical protein binding; molecular adaptor activity; protein binding; protein self-association
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Biological Process:
negative regulation of ER-associated ubiquitin-dependent protein catabolic process; negative regulation of ubiquitin-dependent protein catabolic process; positive regulation of ER-associated ubiquitin-dependent protein catabolic process; post-translational protein targeting to endoplasmic reticulum membrane; tail-anchored membrane protein insertion into ER membrane; ubiquitin-dependent ERAD pathway
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Reference #:
O43765
(UniProtKB)
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Alt. Names/Synonyms: Alpha-SGT; alphaSGT; hSGT; protein containing three tetratricopeptide repeats; SGT; SGT1; SGTA; small glutamine rich tetratricopeptide repeat containing alpha; small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha; Small glutamine-rich tetratricopeptide repeat-containing protein alpha; UBP; Vpu-binding protein
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Gene Symbols: SGTA
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Molecular weight:
34,063 Da
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Basal Isoelectric point:
4.81
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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