BUB3 Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Belongs to the WD repeat BUB3 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of human Ortholog: 10q26.13
Cellular Component:  bub1-bub3 complex; cytosol; kinetochore; mitotic checkpoint complex; nucleoplasm
Molecular Function:  protein binding; ubiquitin binding
Biological Process:  attachment of spindle microtubules to kinetochore; cell division; meiotic cell cycle; mitotic spindle assembly checkpoint signaling; negative regulation of ubiquitin-protein transferase activity; protein localization to kinetochore
Reference #:  O43684 (UniProtKB)
Alt. Names/Synonyms: BUB3; BUB3 budding uninhibited by benzimidazoles 3 homolog; BUB3 mitotic checkpoint protein; BUB3L; budding uninhibited by benomyl; budding uninhibited by benzimidazoles 3 homolog; budding uninhibited by benzimidazoles 3 homolog (yeast); hBUB3; mitotic checkpoint component; Mitotic checkpoint protein BUB3; testicular tissue protein Li 27
Gene Symbols: BUB3
Molecular weight: 37,155 Da
Basal Isoelectric point: 6.36  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene