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DNCLI2
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Belongs to the dynein light intermediate chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 16q22.1 |
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Cellular Component:
centrosome; cytosol; kinetochore; late endosome; lysosome; microtubule
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Molecular Function:
ATP binding; microtubule motor activity
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Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to nerve growth factor stimulus; centrosome localization; ER to Golgi vesicle-mediated transport; protein homooligomerization
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Reference #:
O43237
(UniProtKB)
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Alt. Names/Synonyms: Cytoplasmic dynein 1 light intermediate chain 2; DC1L2; DNCLI2; DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2; Dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic 1, light intermediate chain 2; dynein, cytoplasmic, light intermediate polypeptide 2; LIC-2; LIC2; LIC53/55
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Gene Symbols: DYNC1LI2
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Molecular weight:
54,099 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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