DNCLI2 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Belongs to the dynein light intermediate chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16q22.1
Cellular Component:  centrosome; cytosol; kinetochore; late endosome; lysosome; microtubule
Molecular Function:  ATP binding; microtubule motor activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; cellular response to nerve growth factor stimulus; centrosome localization; ER to Golgi vesicle-mediated transport; protein homooligomerization
Reference #:  O43237 (UniProtKB)
Alt. Names/Synonyms: Cytoplasmic dynein 1 light intermediate chain 2; DC1L2; DNCLI2; DYNC1LI2; Dynein light intermediate chain 2, cytosolic; dynein, cytoplasmic 1, light intermediate chain 2; dynein, cytoplasmic, light intermediate polypeptide 2; LIC-2; LIC2; LIC53/55
Gene Symbols: DYNC1LI2
Molecular weight: 54,099 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
Select Structure to View Below

DNCLI2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene