ataxin-7 Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation. Necessary for microtubule cytoskeleton stabilization. Belongs to the ataxin-7 family. Isoform a and isoform b are expressed in CNS, but isoform a is expressed predominantly in the peripherical tissues. Isoform b is also highly expressed in the frontal lobe, skeletal muscle and spinal cord and is expressed at a lower level in the lung, lymphoblast and intestine. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Transcription regulation
Chromosomal Location of Human Ortholog: 3p14.1
Cellular Component:  cytosol; microtubule cytoskeleton; nuclear matrix; nucleolus; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  histone deubiquitination; microtubule cytoskeleton organization; nucleus organization; protein deubiquitination; visual perception
Disease: Spinocerebellar Ataxia 7
Reference #:  O15265 (UniProtKB)
Alt. Names/Synonyms: ADCAII; ataxin 7; Ataxin-7; ATX7; ATXN7; FLJ17787; OPCA3; SCA7; SGF73; Spinocerebellar ataxia type 7 protein
Gene Symbols: ATXN7
Molecular weight: 95,451 Da
Basal Isoelectric point: 9.89  Predict pI for various phosphorylation states
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ataxin-7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein