BACH1 Transcriptional regulator that acts as repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Play important roles in coordinating transcription activation and repression by MAFK. Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway. Belongs to the bZIP family. CNC subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 21q21.3
Cellular Component:  chromatin; cytosol; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; heme binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Process:  DNA repair; negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription involved in G1/S transition of mitotic cell cycle; regulation of transcription involved in G2/M transition of mitotic cell cycle
Reference #:  O14867 (UniProtKB)
Alt. Names/Synonyms: BACH-1; BACH1; basic region leucine zipper transcriptional regulator BACH1; BTB and CNC homolog 1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; BTB domain and CNC homolog 1; BTBD24; HA2303; Transcription regulator protein BACH1
Gene Symbols: BACH1
Molecular weight: 81,958 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BACH1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein