ARID1A Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Highly expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon, and PBL, and at a much lower level in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component:  nBAF complex; npBAF complex; nuclear chromatin; nucleoplasm; nucleus; SWI/SNF complex
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; nuclear receptor binding; nucleosome binding; protein binding; transcription coactivator activity
Biological Process:  androgen receptor signaling pathway; ATP-dependent chromatin remodeling; cardiac chamber development; cardiac muscle cell differentiation; chromatin remodeling; chromatin-mediated maintenance of transcription; embryo implantation; forebrain development; formation of primary germ layer; glucocorticoid receptor signaling pathway; intracellular estrogen receptor signaling pathway; maintenance of chromatin silencing; negative regulation of transcription by RNA polymerase II; neural tube closure; nucleosome disassembly; nucleosome mobilization; optic cup formation involved in camera-type eye development; placenta blood vessel development; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; stem cell population maintenance; toxin transport
Disease: Mental Retardation, Autosomal Dominant 14
Reference #:  O14497 (UniProtKB)
Alt. Names/Synonyms: ARI1A; ARID domain-containing protein 1A; ARID1A; AT rich interactive domain 1A (SWI- like); AT rich interactive domain 1A (SWI-like); AT-rich interactive domain-containing protein 1A; B120; BAF250; BAF250A; BM029; brain protein 120; BRG1-associated factor 250; BRG1-associated factor 250a; C1orf4; chromatin remodeling factor p250; hELD; hOSA1; Osa homolog 1; OSA1; OSA1 nuclear protein; P270; SMARCF1; SWI-like protein; SWI/SNF complex protein p270; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1; SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1
Gene Symbols: ARID1A
Molecular weight: 242,045 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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