Bcl-9 Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity. Belongs to the BCL9 family. Detected at low levels in thymus, prostate, testis, ovary and small intestine, and at lower levels in spleen, colon and blood. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1q21.2
Cellular Component:  beta-catenin-TCF complex; cis-Golgi network; nucleoplasm
Molecular Function:  beta-catenin binding; protein binding; transcription coactivator activity
Biological Process:  beta-catenin-TCF complex assembly; canonical Wnt signaling pathway; myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription by RNA polymerase II; skeletal muscle cell differentiation; somatic stem cell population maintenance
Reference #:  O00512 (UniProtKB)
Alt. Names/Synonyms: B cell CLL/lymphoma 9; B-cell CLL/lymphoma 9; B-cell CLL/lymphoma 9 protein; B-cell lymphoma 9 protein; Bcl-9; BCL9; BCL9 transcription coactivator; LGS; MGC131591; Protein legless homolog
Gene Symbols: BCL9
Molecular weight: 149,290 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
CST Pathways:  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Bcl-9

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein