BIN1 Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Is a negative regulator of endocytosis. Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production. In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates. May be involved in the regulation of MYC activity and the control cell proliferation. Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro. Ubiquitous. Highest expression in the brain and muscle (PubMed:9182667). Expressed in oligodendrocytes (PubMed:27488240). Isoform IIA is expressed only in the brain, where it is detected in the gray matter, but not in the white matter (PubMed:27488240). Isoform BIN1 is widely expressed with highest expression in skeletal muscle. 11 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Cytoskeletal; Tumor suppressor; Vesicle
Chromosomal Location of Human Ortholog: 2q14.3
Cellular Component:  actin cytoskeleton; axon; axon initial segment; cytoplasm; cytosol; endosome; I band; lipid tube; membrane; node of Ranvier; nuclear envelope; nucleus; T-tubule; Z disc
Molecular Function:  actin filament binding; chaperone binding; clathrin binding; identical protein binding; protease binding; protein binding; RNA polymerase binding; tau protein binding
Biological Process:  cytoskeleton organization; endocytosis; endosome to lysosome transport; lipid tube assembly; membrane organization; negative regulation of amyloid-beta formation; negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel; negative regulation of potassium ion transmembrane transport; negative regulation of ventricular cardiac muscle cell action potential; nucleus localization; nucleus organization; positive regulation of actin filament polymerization; positive regulation of apoptotic process; positive regulation of astrocyte differentiation; regulation of cell cycle arrest; regulation of endocytosis; regulation of heart rate by cardiac conduction; regulation of neuron differentiation; T-tubule organization; viral process
Disease: Myopathy, Centronuclear, 2
Reference #:  O00499 (UniProtKB)
Alt. Names/Synonyms: AMPH2; Amphiphysin II; Amphiphysin-like protein; AMPHL; BIN1; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; CNM2; DKFZp547F068; MGC10367; Myc box-dependent-interacting protein 1; SH3P9
Gene Symbols: BIN1
Molecular weight: 64,699 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene