MYO1C Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Contractile; Lipid-binding; Motility/polarity/chemotaxis; Motor; Nucleolus
Chromosomal Location of Human Ortholog: 17p13.3
Cellular Component:  basal plasma membrane; brush border; cytoplasm; cytoplasmic vesicle membrane; cytosol; filamentous actin; lateral plasma membrane; membrane; membrane raft; microvillus; nuclear body; nuclear pore; nucleolus; nucleoplasm; phagocytic vesicle; plasma membrane; ruffle membrane; stereocilium membrane; unconventional myosin complex
Molecular Function:  actin filament binding; actin-dependent ATPase activity; ATP binding; calmodulin binding; microfilament motor activity; protein binding; protein C-terminus binding; Ral GTPase binding; signaling receptor binding
Biological Process:  cellular response to interferon-gamma; Fc-gamma receptor signaling pathway involved in phagocytosis; mRNA transport; positive regulation of actin filament polymerization; positive regulation of cell migration; positive regulation of cell migration by vascular endothelial growth factor signaling pathway; positive regulation of cellular response to insulin stimulus; positive regulation of gene expression, epigenetic; positive regulation of protein targeting to membrane; positive regulation of vascular endothelial growth factor signaling pathway; protein targeting; protein targeting to membrane; regulation of bicellular tight junction assembly; vesicle transport along actin filament
Reference #:  O00159 (UniProtKB)
Alt. Names/Synonyms: FLJ23903; MMI-beta; MMIb; MYO1C; Myosin I beta; myosin IC; myosin-I beta; Myosin-Ic; myr2; NMI; nuclear myosin I; Unconventional myosin-Ic
Gene Symbols: MYO1C
Molecular weight: 121,682 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein