CASP6
Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Belongs to the peptidase C14A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Apoptosis; EC 3.4.22.59; Protease |
Chromosomal Location of rat Ortholog: 2q43 |
Cellular Component:
axon; caspase complex; cytoplasm; cytosol; neuronal cell body; nucleolus; nucleoplasm; nucleus
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Molecular Function:
cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; endopeptidase activity; identical protein binding
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Biological Process:
activation of cysteine-type endopeptidase activity; activation of innate immune response; acute inflammatory response to non-antigenic stimulus; animal organ development; apoptotic process; axonal fasciculation; cellular response to staurosporine; epithelial cell differentiation; execution phase of apoptosis; hepatocyte apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; lens development in camera-type eye; positive regulation of apoptotic process; positive regulation of necroptotic process; positive regulation of neuron apoptotic process; positive regulation of retinal cell programmed cell death; protein autoprocessing; proteolysis; pyroptosis; regulation of programmed cell death; response to cytokine; response to estradiol; response to gamma radiation; response to glucose; response to hydrogen peroxide; response to iron ion; response to metal ion; response to organic substance; response to organonitrogen compound; response to testosterone; system development
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Reference #:
O35397
(UniProtKB)
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Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; Casp6; caspase 6; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; Mch2; MGC93335
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Gene Symbols: Casp6
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Molecular weight:
31,556 Da
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Basal Isoelectric point:
6.46
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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ErbB/HER Signaling
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Inhibition of Apoptosis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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