ARMET Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions. Belongs to the ARMET family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of mouse Ortholog: 9 F1|9 57.98 cM
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum lumen; extracellular region; extracellular space; perinuclear region of cytoplasm; sarcoplasmic reticulum
Molecular Function:  growth factor activity; lipid binding; sulfatide binding
Biological Process:  dopaminergic neuron differentiation; neuron projection development; regulation of response to endoplasmic reticulum stress; response to unfolded protein; vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure
Reference #:  Q9CXI5 (UniProtKB)
Alt. Names/Synonyms: 3230402M22Rik; AA407711; AA408789; AA673178; Arginine-rich protein; arginine-rich, mutated in early stage tumors; Arm; Armet; D17914; D18Mgi17; Manf; Mesencephalic astrocyte-derived neurotrophic factor; Protein ARMET
Gene Symbols: Manf
Molecular weight: 20,388 Da
Basal Isoelectric point: 8.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein