RGS9 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction. Highly expressed in the caudate and putamen, lower levels found in the hypothalamus and nucleus accumbens and very low levels in cerebellum. Not expressed in globus pallidus or cingulate cortex. Isoform 2 is expressed predominantly in pineal gland and retina. Isoform 3 is expressed in retina (abundant in photoreceptors). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, RGS
Cellular Component:  photoreceptor disc membrane
Molecular Function:  protein binding
Biological Process:  G protein-coupled receptor signaling pathway; intracellular signal transduction; negative regulation of signal transduction; visual perception
Reference #:  O46469 (UniProtKB)
Alt. Names/Synonyms: Regulator of G-protein signaling 9; RGS9
Gene Symbols: RGS9
Molecular weight: 56,680 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs
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RGS9

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene