SEC24C Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B. May more specifically package GPI-anchored proteins through the cargo receptor TMED10. May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5. Belongs to the SEC23/SEC24 family. SEC24 subfamily. Ubiquitous. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motor
Chromosomal Location of Human Ortholog: 10q22.2
Cellular Component:  COPII vesicle coat; cytosol; endoplasmic reticulum membrane; ER to Golgi transport vesicle membrane; Golgi membrane
Molecular Function:  protein binding; SNARE binding; zinc ion binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; cargo loading into COPII-coated vesicle; COPII vesicle coating; ER to Golgi vesicle-mediated transport; in utero embryonic development; intracellular protein transport
Reference #:  P53992 (UniProtKB)
Alt. Names/Synonyms: KIAA0079; Protein transport protein Sec24C; SC24C; SEC24 family, member C (S. cerevisiae); SEC24 related gene family, member C; SEC24-related protein C; SEC24C
Gene Symbols: SEC24C
Molecular weight: 118,325 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein