KPNA1 Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Belongs to the importin alpha family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Karyopherin; Nuclear import
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component:  cytoplasm; cytosol; dendrite; nuclear pore; nucleoplasm; nucleus
Molecular Function:  nuclear localization sequence binding; protein binding; protein transporter activity
Biological Process:  apoptotic DNA fragmentation; modulation by virus of host process; NLS-bearing substrate import into nucleus; regulation of DNA recombination
Reference #:  P52294 (UniProtKB)
Alt. Names/Synonyms: IMA1; importin alpha 5; Importin subunit alpha-1; Importin subunit alpha-5; importin-alpha-S1; IPOA5; karyopherin alpha 1; karyopherin alpha 1 (importin alpha 5); Karyopherin subunit alpha-1; KPNA1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; RCH2; recombination activating gene cohort 2; SRP1; SRP1-beta
Gene Symbols: KPNA1
Molecular weight: 60,222 Da
Basal Isoelectric point: 4.94  Predict pI for various phosphorylation states
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KPNA1

Protein Structure Not Found.


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