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KPNA1
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. Belongs to the importin alpha family. Expressed ubiquitously. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Karyopherin; Nuclear import |
| Chromosomal Location of human Ortholog: 3q21.1 |
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Cellular Component:
cytoplasm; cytosol; dendrite; glutamatergic synapse; NLS-dependent protein nuclear import complex; nuclear pore; nucleoplasm; nucleus; postsynaptic density
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Molecular Function:
nuclear import signal receptor activity; nuclear localization sequence binding; protein binding
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Biological Process:
NLS-bearing protein import into nucleus; postsynapse to nucleus signaling pathway; protein import into nucleus; regulation of apoptotic process; regulation of canonical Wnt signaling pathway; regulation of DNA recombination; satellite cell activation involved in skeletal muscle regeneration; skeletal muscle satellite cell proliferation
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Reference #:
P52294
(UniProtKB)
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Alt. Names/Synonyms: IMA1; IMA5; importin alpha 5; Importin subunit alpha-1; Importin subunit alpha-5; Importin subunit alpha-5, N-terminally processed; importin-alpha-S1; IPOA5; karyopherin alpha 1; karyopherin alpha 1 (importin alpha 5); karyopherin subunit alpha 1; Karyopherin subunit alpha-1; KPNA1; NPI-1; Nucleoprotein interactor 1; RAG cohort protein 2; RCH2; recombination activating gene cohort 2; SRP1; SRP1-beta
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Gene Symbols: KPNA1
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Molecular weight:
60,222 Da
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Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
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