ANKRD3 Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Expressed in hair follicles and skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component:  cytoplasm; membrane
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  morphogenesis of an epithelium; positive regulation of NF-kappaB transcription factor activity; protein phosphorylation
Disease: Chand Syndrome; Popliteal Pterygium Syndrome, Lethal Type
Reference #:  P57078 (UniProtKB)
Alt. Names/Synonyms: ANKK2; ANKRD3; ankyrin repeat domain 3; Ankyrin repeat domain-containing protein 3; DIK; MGC129992; MGC129993; PKC-delta-interacting protein kinase; PKK; receptor-interacting serine-threonine kinase 4; Receptor-interacting serine/threonine-protein kinase 4; RIP4; RIPK4; serine/threonine-protein kinase ANKRD3
Gene Symbols: RIPK4
Molecular weight: 91,611 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

ANKRD3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein