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ANKRD3
Involved in stratified epithelial development. It is a direct transcriptional target of TP63. Plays a role in NF-kappa-B activation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Expressed in hair follicles and skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group |
| Chromosomal Location of human Ortholog: 21q22.3 |
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Cellular Component:
cytoplasm; membrane
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Molecular Function:
ATP binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
morphogenesis of an epithelium; positive regulation of NF-kappaB transcription factor activity; protein phosphorylation
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Disease: Chand Syndrome; Popliteal Pterygium Syndrome, Lethal Type
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Reference #:
P57078
(UniProtKB)
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Alt. Names/Synonyms: ANKK2; ANKRD3; ankyrin repeat domain 3; Ankyrin repeat domain-containing protein 3; CHANDS; DIK; MGC129992; MGC129993; NKRD3; PKC-delta-interacting protein kinase; PKK; PPS2; protein kinase C-associated kinase; receptor interacting serine/threonine kinase 4; receptor-interacting serine-threonine kinase 4; Receptor-interacting serine/threonine-protein kinase 4; RIP4; RIPK4; serine/threonine-protein kinase ANKRD3
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Gene Symbols: RIPK4
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Molecular weight:
91,611 Da
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Basal Isoelectric point:
6.69
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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