IRX2 Belongs to the TALE/IRO homeobox family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of human Ortholog: 5p15.33
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding
Biological Process:  negative regulation of transcription by RNA polymerase II; proximal/distal pattern formation involved in metanephric nephron development; specification of loop of Henle identity
Reference #:  Q9BZI1 (UniProtKB)
Alt. Names/Synonyms: Homeodomain protein IRXA2; iroquois homeobox 2; Iroquois homeobox protein 2; Iroquois-class homeodomain protein IRX-2; IRX2; IRXA2
Gene Symbols: IRX2
Molecular weight: 49,129 Da
Basal Isoelectric point: 5.14  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein