neurofascin Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1 E4|1 57.42 cM
Cellular Component:  axon; axon initial segment; dendrite; integral component of membrane; integral component of plasma membrane; membrane; node of Ranvier; paranodal junction; paranode region of axon; plasma membrane; Schwann cell microvillus; septate junction
Molecular Function:  protein binding; protein binding involved in heterotypic cell-cell adhesion; protein domain specific binding
Biological Process:  axon guidance; cell adhesion; clustering of voltage-gated sodium channels; myelination; paranodal junction assembly; peripheral nervous system development; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; synapse organization; transmission of nerve impulse
Reference #:  Q810U3 (UniProtKB)
Alt. Names/Synonyms: AA387016; D430023G06Rik; mKIAA0756; neurofascin; NF; Nfasc
Gene Symbols: Nfasc
Molecular weight: 137,975 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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neurofascin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein