neurofascin Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 13 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 13q13
Cellular Component:  axon; dendrite; integral component of membrane; intracellular; myelin sheath; paranode region of axon; plasma membrane
Molecular Function:  protein binding involved in heterotypic cell-cell adhesion; protein domain specific binding
Biological Process:  axon guidance; clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; myelination; paranodal junction assembly; peripheral nervous system development; protein localization to plasma membrane; synapse organization; transmission of nerve impulse
Reference #:  P97685 (UniProtKB)
Alt. Names/Synonyms: Neurofascin; NF; Nfasc
Gene Symbols: Nfasc
Molecular weight: 138,004 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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neurofascin

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene