IL28RA The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Belongs to the type II cytokine receptor family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 1p36.11
Cellular Component:  interleukin-28 receptor complex; membrane; plasma membrane
Molecular Function:  cytokine receptor activity; protein binding
Biological Process:  cellular response to virus; cytokine-mediated signaling pathway; defense response to virus; mucosal immune response; negative regulation of cell population proliferation; positive regulation of cellular respiration; regulation of defense response to virus by host; response to type III interferon; type III interferon-mediated signaling pathway
Reference #:  Q8IU57 (UniProtKB)
Alt. Names/Synonyms: class II cytokine receptor CRF2/12; CRF2-12; CRF2/12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; I28RA; IFN-lambda receptor 1; IFN-lambda-R1; IFNLR; IFNLR1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28R1; IL-28RA; IL28RA; INLR1; Interferon lambda receptor 1; interferon lambda, receptor 1; interleukin 28 alpha receptor; interleukin 28 receptor A; interleukin 28 receptor, alpha (interferon, lambda receptor); interleukin or cytokine receptor 2; Interleukin-28 receptor subunit alpha; LICR2; Likely interleukin or cytokine receptor 2
Gene Symbols: IFNLR1
Molecular weight: 57,653 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein