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CCND3
Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Belongs to the cyclin family. Cyclin D subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator |
| Chromosomal Location of rat Ortholog: 9q12 |
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Cellular Component:
cyclin D3-CDK4 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; nucleoplasm; nucleus
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Molecular Function:
cyclin-dependent protein serine/threonine kinase activator activity; cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase binding
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Biological Process:
cell division; G1/S transition of mitotic cell cycle; hyaluronan biosynthetic process; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of protein phosphorylation; regulation of cell cycle; regulation of cell population proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; response to glucose; response to organic substance; response to peptide hormone; signal transduction; T cell proliferation
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Reference #:
P48961
(UniProtKB)
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Alt. Names/Synonyms: Ccnd3; cyclin D3; G1/S-specific cyclin-D3; MGC108760; MGC93643
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Gene Symbols: Ccnd3
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Molecular weight:
32,434 Da
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Basal Isoelectric point:
5.81
Predict pI for various phosphorylation states
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CST Pathways:
G1/S Checkpoint
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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