CCND3 Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Belongs to the cyclin family. Cyclin D subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation; Nuclear receptor co-regulator
Chromosomal Location of mouse Ortholog: 17 C|17 23.37 cM
Cellular Component:  cyclin-dependent protein kinase holoenzyme complex; cytoplasm; membrane; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase activity; cyclin-dependent protein serine/threonine kinase regulator activity; protein binding; protein kinase binding
Biological Process:  cell cycle; cell division; hyaluronan biosynthetic process; mitotic cell cycle phase transition; negative regulation of transcription by RNA polymerase II; positive regulation of cell proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of protein phosphorylation; regulation of cell cycle; regulation of cell proliferation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of insulin receptor signaling pathway; response to peptide hormone; signal transduction; T cell proliferation
Reference #:  P30282 (UniProtKB)
Alt. Names/Synonyms: 9230106B05Rik; AA682053; AL024085; AW146355; C78795; Ccnd3; cyclin D3; Cyl-3; G1/S-specific cyclin-D3
Gene Symbols: Ccnd3
Molecular weight: 32,411 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA