ADRA1B a G protein-coupled catecholamine receptor that activates mitogenic responses and regulates growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Can induce neoplastic transformation when transfected into cell lines. Can regulate the phosphorylation status of the STAT3 pathway. Mediates blood pressure and aorta contractile responses induced by alpha-1 agonists. Activates a phosphatidylinositol second messenger system. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 10q21
Cellular Component:  caveola; cytoplasm; integral component of membrane; integral component of plasma membrane; intercalated disc; membrane; nuclear membrane; nucleus; plasma membrane; T-tubule
Molecular Function:  adrenergic receptor activity; alpha1-adrenergic receptor activity; protein binding; protein heterodimerization activity
Biological Process:  adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adrenergic receptor signaling pathway; adult heart development; behavioral response to cocaine; blood vessel remodeling; cell growth involved in cardiac muscle cell development; glucose homeostasis; locomotory behavior; negative regulation of glycogen catabolic process; negative regulation of Rho protein signal transduction; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; organ growth; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; positive regulation of glycogen catabolic process; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of MAPK cascade; positive regulation of smooth muscle contraction; positive regulation of the force of heart contraction by epinephrine-norepinephrine; positive regulation of vasoconstriction; regulation of cardiac muscle contraction; regulation of vasoconstriction; response to amphetamine; response to drug; response to estrogen; response to hormone; response to morphine; response to steroid hormone; vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure; visual learning
Reference #:  P15823 (UniProtKB)
Alt. Names/Synonyms: ADA1B; Adra1b; Adrenergic alpha 1B- receptor; adrenergic receptor, alpha 1b; adrenergic, alpha-1B-, receptor; alpha 1B-adrenoceptor; alpha 1B-adrenoreceptor; Alpha-1B adrenergic receptor; Alpha-1B adrenoceptor; Alpha-1B adrenoreceptor
Gene Symbols: Adra1b
Molecular weight: 56,586 Da
Basal Isoelectric point: 9.3  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene